GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1577917 | 1 | rs68171315 | chr6:86707400 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -10.83 | 1.35E-24 | Response to antipsychotic treatment |
| THCA | cis | rs59374417 | 1 | rs68180496 | chr3:119278915 | ADPRH | chr3:119298523-119308791:+ | -0.22 | -3.6 | 0.000347 | Vitiligo |
| THCA | cis | rs9346353 | 1 | rs68181489 | chr6:70487027 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.4 | 0.000729 | Sleep duration |
| THCA | cis | rs8180209 | 1 | rs6818319 | chr4:90642868 | MMRN1 | chr4:90816003-90875778:+ | 0.32 | 4.04 | 6.27E-5 | Parkinson's disease |
| THCA | cis | rs8030605 | 1 | rs68187092 | chr15:56380718 | MNS1 | chr15:56720929-56757335:- | -0.26 | -3.82 | 0.000151 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs68187092 | chr15:56380718 | TEX9 | chr15:56657644-56738071:+ | -0.36 | -6.26 | 8.64E-10 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs2243480 | 1 | rs68189316 | chr7:65409169 | CCT6P1 | chr7:65216092-65228661:+ | 0.39 | 6.18 | 1.36E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs68189316 | chr7:65409169 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.99 | 7.58E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs68189316 | chr7:65409169 | RABGEF1 | chr7:66093890-66276446:+ | 0.54 | 6.71 | 5.64E-11 | Diabetic kidney disease |
| THCA | cis | rs6832769 | 1 | rs6819660 | chr4:56374577 | TMEM165 | chr4:56262090-56292342:+ | -0.16 | -4.1 | 4.79E-5 | Personality dimensions |
| THCA | cis | rs7665090 | 1 | rs6821119 | chr4:103555233 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.31 | 2.03E-5 | Primary biliary cirrhosis |
| THCA | cis | rs7692995 | 1 | rs6821168 | chr4:18005019 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.49 | 8.81E-6 | Height |
| THCA | cis | rs4691139 | 1 | rs6821283 | chr4:165901645 | C4orf39 | chr4:165878100-165880273:+ | 0.2 | 5.53 | 5.14E-8 | Ovarian cancer in BRCA1 mutation carriers |
| THCA | cis | rs11097912 | 1 | rs6823347 | chr4:106962725 | TBCK | chr4:106967233-107237861:- | 0.33 | 6.81 | 2.9E-11 | Airflow obstruction |
| THCA | cis | rs7659604 | 1 | rs6823488 | chr4:122664819 | EXOSC9 | chr4:122722472-122738175:+ | 0.15 | 3.84 | 0.000137 | Type 2 diabetes |